Our Methodology

How PipelineEvidence sources, verifies, and maintains the data behind 218+ approved cancer therapies across 50 tumor types.

Primary Data Sources

Every data point on PipelineEvidence traces back to an authoritative primary source. We do not aggregate from secondary databases or unverified compilations.

FDA Prescribing Information

Complete package inserts from DailyMed and Drugs@FDA — the definitive source for US-approved indications, dosing, contraindications, warnings, adverse reactions, and pharmacology.

ClinicalTrials.gov

The US National Library of Medicine registry for clinical trials. We reference NCT numbers, study designs, enrollment figures, interventions, and primary endpoints for all pivotal trials.

EMA & EU Clinical Trials Register

European Medicines Agency assessments and the EudraCT registry provide regulatory context for therapies with both US and EU market authorization.

NCI SEER Program

The Surveillance, Epidemiology, and End Results program provides cancer incidence, mortality, staging distribution, and survival statistics for 26 major tumor types on our platform.

Peer-Reviewed Publications

Primary publications from the New England Journal of Medicine, Lancet Oncology, Journal of Clinical Oncology, and other high-impact journals for pivotal trial results.

NCCN & Clinical Guidelines

National Comprehensive Cancer Network guidelines inform our editorial context on treatment landscapes and standards of care.

What Each Drug Profile Contains

Every drug profile is structured as a navigable package insert with standardized sections:

1
Indications & Usage — Complete FDA-approved indications covering all tumor types and treatment settings.
2
Dosage & Administration — Precise dosing, route, schedule, cycle length, dose modifications, and combination regimens.
3
Warnings & Adverse Reactions — Black box warnings, contraindications, common adverse reactions with animated incidence bars, and serious adverse events.
4
Clinical Pharmacology — Mechanism of action, pharmacokinetics (half-life, Vd, clearance), and pharmacodynamics.
5
Pivotal Clinical Trials — Named trial identifiers, NCT numbers with direct ClinicalTrials.gov links, and PubMed links to primary publications.
6
Cross-Referenced Tumor Types — Links to every tumor page where the drug has an approved indication.

Tumor Page Structure

Each of our 50 tumor type pages is organized into standardized sections:

Approved Therapies

Complete table of FDA-approved drugs organized by drug class and mechanism of action.

Clinical Trial Pipeline

Active Phase 1–3 trials with NCT/EudraCT numbers, interventions, endpoints, and registry links.

Molecular Biology

Genomic landscape, actionable mutations, biomarker testing guidance, and molecular subtyping.

SEER Epidemiology

Incidence, mortality, 5-year survival by stage, demographics, and temporal trends from NCI SEER.

Treatment Landscape

Editorial overview of current treatment paradigms and evolving standards of care.

FAQ with Schema

Frequently asked questions with structured data markup for enhanced search visibility.

Quality Assurance & Editorial Process

Accuracy is non-negotiable in oncology. Our editorial process includes:

Primary Source Verification

Every drug indication, dose, adverse reaction rate, and trial reference is verified against the current FDA prescribing information (via DailyMed) and ClinicalTrials.gov. We do not rely on secondary compilations.

Cross-Referencing

Clinical data points are cross-referenced between FDA labels, primary trial publications, and supplemental ASCO/ESMO presentations when available.

Regular Updates

The database is updated to reflect new FDA approvals, supplemental indications, label changes, safety communications, and newly published trial data.

Error Reporting

We encourage users to report errors or outdated information via our contact page. All reported discrepancies are investigated promptly.

Technical Standards

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Schema.org Markup

MedicalWebPage, Drug, FAQPage, Article, and BreadcrumbList schemas across all pages.

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Responsive Design

Mobile-first layout for phones, tablets, and desktops.

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Global CDN

Deployed on Cloudflare Pages for fast delivery with SSL encryption.

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Print-Friendly

Optimized print styles for generating clean PDF versions of drug profiles.

Limitations & Disclaimer

PipelineEvidence is an informational resource, not a clinical decision-support tool. While we strive for accuracy, the information on this platform should not replace consultation of official prescribing information or the judgment of a qualified healthcare professional.

For clinical decision-making, always consult the current FDA prescribing information, institutional protocols, and your healthcare team. Read our full medical disclaimer.

Feedback & Contact

We value input from patients, clinicians, pharmacists, researchers, and industry professionals. If you have corrections, suggestions, or questions about our methodology, please reach out through our contact page.

For partnership, sponsorship, or data licensing inquiries: info@pipelineevidence.com