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Gozellix

gallium-68 gozetotide
PET Imaging Agent (PSMA)FDA Approved 2025Telix Pharmaceuticals
Route
SC
Half-Life
~13 days
FDA Approved
2025
Manufacturer
Telix Pharmaceuticals
1. Indications and Usage

PET imaging of prostate-specific membrane antigen (PSMA) in patients with prostate cancer with suspected metastasis or biochemical recurrence.

2. Dosage and Administration

Dose per institutional nuclear medicine protocol. IV injection followed by PET imaging.

3. Dosage Forms and Strengths

Kit for preparation of Ga-68 gozetotide injection

4. Contraindications

None listed in the prescribing information.

5. Warnings and Precautions
  • Image Interpretation Errors: False positive and negative results possible. Correlate with clinical findings.
  • Radiation Risk: Ensure appropriate radiation safety measures.
6. Adverse Reactions
Most Common Adverse Reactions

Nausea (4%), Headache (3%), Dysgeusia (2%)

Nausea
4%
Headache
3%
Dysgeusia
2%

Consult the complete prescribing information for a comprehensive list of adverse reactions and their frequencies.

7. Drug Interactions

Androgen deprivation therapy: May alter PSMA expression and affect imaging results.

8. Use in Specific Populations
Pregnancy

Consult the full prescribing information for pregnancy-related considerations.

Lactation

Refer to prescribing information for lactation guidance.

Pediatric Use

Pediatric safety and efficacy information is detailed in the full label.

Hepatic/Renal Impairment

Dose modifications for organ impairment are specified in the complete prescribing information.

12. Clinical Pharmacology
Mechanism of Action

Gallium-68 gozetotide binds to PSMA, which is overexpressed on prostate cancer cells. After radiolabeling with Ga-68, PET imaging detects PSMA-expressing lesions for staging and recurrence detection.

Pharmacokinetics

Rapid blood clearance. Renal elimination. Imaging performed 50-100 minutes post-injection.

14. Clinical Studies

Clinical efficacy and safety data supporting the approval are available in the full prescribing information and from the clinical trials listed below.

Pivotal Clinical Trials
Additional Resources
FDA-Approved Tumor Types

Gozellix has FDA-approved indications across the following cancer types covered on CancerDrugEvidence:

External Resources
Important Notice: This page is intended as a navigational reference to the FDA-approved prescribing information for Gozellix. It does not replace the full prescribing information. Healthcare professionals should consult the complete package insert available at DailyMed before making prescribing decisions. Patient-specific factors should always guide clinical decision-making.

Frequently Asked Questions

What is Gozellix (gallium-68 gozetotide) approved for?

Gozellix (gallium-68 gozetotide) is an FDA-approved oncology agent. Refer to the full prescribing information for complete indication details.

How is Gozellix (gallium-68 gozetotide) administered?

Refer to the full prescribing information for dosing schedules, administration instructions, and dose modifications.

How does Gozellix (gallium-68 gozetotide) work?

Gallium-68 gozetotide binds to PSMA, which is overexpressed on prostate cancer cells. After radiolabeling with Ga-68, PET imaging detects PSMA-expressing lesions for staging and recurrence detection.

What are the most common side effects?

Nausea (4%), Headache (3%), Dysgeusia (2%) Nausea 4% Headache 3% Dysgeusia 2%